Wissenschaftliche Literatur

Weltweit wurde eine Vielzahl an Studien mit Bioaktiven Kollagenpeptiden an renommierten Instituten und Universitäten durchgeführt. Die Studien zeigen nach höchsten wissenschaftlichen Standards den erfolgreichen Einsatz der spezifischen Bioaktiven Kollagenpeptide für die jeweilige Gruppe.

Adeva-Andany, Souto-Adeva, Ameneiros-Rodríguez, Fernández-Fernández, Donapetry-García, Domínguez-Montero Insulin resistance and glycine metabolism in humans Amino Acids (2018) 50:11-27

Asserin, Lati, Shioya, Eng, Prawitt The effect of oral collagen peptide supplementation on skin moisture and dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials JCD (2015), 0:1-11

Axenfeld, Pau: Lehrbuch der Augenheilkunde. Gusav Fischer, Stuttgart 1980

Bello, Oesser Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review oft the literature Cur Med Res Opin 2006 (22), No 11, 2221-2232 doi:10.1185/030079906X148373

Berdanier C.D., Berdanier L. A. Advanced Nutrition second edition 2015, CRC Press ISBN 978-1-4822-0517-6

Berke Biologie des Auges. Mainz: WVAO, 1999 (2.Auflage)

Boullata, Armenti (ed.) Handbook of Drug-Nutrient Interactions 2nd edition Humana Press 2010 ISBN 978-1-60327-363-3

Boullata, Hudson Drug-nutrient interactions: a broad view with implications for practice Journal of the Academy of Nutrition and Dietetics April 2012 Vol 112 No 4:506-517

Bruyère, Zegels, Leonori, Rabenda, Janssen, Bourges, Reginster Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study Complement Ther Med (2012) DOI:10.1016/j.ctim.2011.12.007

Calvez, Poupin, Chesneau, Lassale, Tomé Protein intake, calcium balance and health consequences Eur J Clin Nutr (2012) 66, 281-295

Castellanos, Litchford, Campbell Modular Protein Supplements and Their Application to Long-Term Care Nutrition in Clinical Practice 21:485-504, Oct 2006

Chakrabarti, Guha, Majumder Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities Nutrients 2018, 10, 1738; doi:10.3390/nu10111738

Clatici, Racoceanu, Dalle, Voicu, Tomas-Aragones, Marron, Wollina, Fica Percieved age and life style. The specific contributions of seven factors involved in health and beauty Maedica 2017, 12(3): 191-201

Cole, Quan, Voorhees, Fisher Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging J Cell Commun Signal (2018) 12:35-43

Daliri, Oh, Lee Bioactive Peptides Foods 2017, 6, 32

Daneault, Prawitt, Soulé, Coxam, Wittrant (2017) Biological effect of hydrolyzed collagen on bone metabolism, Critical Review in Food Science and Nutrition, 57:9, 1922-1937 DOI:10.1080/10408398.2015.1038377

Dickinson, Rasmussen Amino acid transporter in the regulation of human skeletal muscle protein metabolism Curr Opin Clin Nutr Metab Care 2013 Nov; 16(6):638-644

Dobenecker, Reese, Jahn, Schunk, Hugenberg, Louton, Oesser Specific bioactive collagen peptides (Petagile®) as supplement for horses with osteoarthritis: a two-centred study J Anim Physiol Anim Nutr. 2018;102(Suppl.1):16-23 DOI: 10.1111(jpn.12863

Dressler, Gehring, Zdzieblik, Oesser, Gollhofer, König Improvement of functional ankle properties following supplementation with specific collagen peptides in athletes with chronic ankle instability Journal of Sports Science and Medicine (2018) 17, 298-304

Duan, Li F., Li Y., Tang, Kong, Feng, Anthony, Watford, Hou, Wu, Yin The role of leucine and its metabolites in protein and energy metabolism Amino Acids (2016) 48:4151

Dunstan, Macdonald, Murphy, Thorn, Roberts Modelling of protein turnover provides insight for metabolic demands on those specific amino acids utilised at disproportionately faster rates than other amino acids Amino Acids (2019) 51: 945 https://doi.org/10.1007/s00726-019-02734-1

Dybka, Walczak Collagen hydrolysates as a new diet supplement Food Chemistry and Biotechnology 2009,73:83-92

EFSA Journal 2012;10(2):2557

Elango, Sanchez, Sánchez de Val, Henrotin, Wang, Motaung, Guo, Wang, Robinson, Regenstein, Bao, Wu Cross-talk between primary osteocytes and bone marrow macrophages for osteoclastogenesis upon collagen treatment, Scientific Reports (2018)8:5318 DOI:10.1038/s41598-018-23532-x

Fisher, Varani, Voorhees Looking older: fibroblast collapse and therapeutic implications Arch Dermatol 2008 May; 144(5):666-672

Frassetto, Morris, Sellmeyer, Todd, Sebastian Diet, evolution and aging Eur J Nutr 40:200-213 (2001)

Fu, Therkildsen, Aluko, Lametsch (2018): Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: successes and challenges, Critical Reviews in Food Science and Nutrition, DOI:10.1080/10408398.2018.1436038

Gòmez-Guillén, Giménez, López-Caballero, Montero Functional and bioactive properties of collagen and gelatin from alternative sources: a review Food Hydrocolloids 25 (2011) 1813-1827

Gonçalves Impact of collagen hydrolysate in middle-aged athletes with knee and ankle osteochondral lesions: A case series Int J Case Rep Images 2017;8(6):364–369.

Goolsby, Boniquit Bone health in athletes: the role of exercise, nutrition and hormones Sports Health 2017 Mar/Apr;9(2):108-117, DOI: 10.1177/1941738116677732

Hays, Kim, Wells et al (2009) Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women J Am Diet Assoc 109, 1082-1087

Helal, Fick-Brosnahan, Reed-Gitomer, Schrier Glomerular hyperfiltration: definitions, mechanisms and clinical implications Nar. Rev. Nephrol. 8, 293-300 (2012)

Hettiarachchy, N. (Ed.), Sato, K. (Ed.), Marshall, M. (Ed.), Kannan, A. (Ed.). (2012). Food Proteins and Peptides. Boca Raton: CRC Press.

Hexsel, Zague, Schunk, Siega Camozzato Oesser Oral suppementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails J Cosmet Dermatol 2017;00:1-7

Hoffer Human Protein and Amino Acid Requirements Journal of Parenteral and Enteral Nutrition Vol 40 No 4 May 2016 460-474

Iismaa, Kaidonis, Nicks, Bogush, Kikuchi, Naqvi, Harvey, Husain, Graham Comparative regenerative mechanism across different mammalian tissues npj Regenerative Medicine (2018) 3:6, DOI:10.1038/s4153-018-0044-5

Kamper, Strandgaard Long-Term Effects of High-Protein Diets on Renal Function Annu. Rev. Nutr. 2017.37:347-69

Karpouzos, Diamantis, Farmaki, Savvanis, Troupis Nutritional aspects of bone health and fracture healing Journal of Osteoporosis (2017) DOI:10.1155/2017/4218472

KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease Vol 3 Issue 1 Jan 2013 (www.kidney-international.org)

van de Kerkhof, Pasch, Scher, Kerscher, Gieler, Haneke, Fleckmann Brittle nail syndrome: a pathogenesis-based approach with a proposed grading system J Am Acad Dermatol 53(4):644-651 Okt 2005

Knefeli, Durani Improved wound healing after oral application of specific bioactive collagen peptides Nutrafoods (2017) 9-12

König, Oesser, Scharla, Zdzieblik, Gollhofer Specific collagen peptides improve bone mineral density and bone markers in postmenopausal women – a randomized controlled study Nutrients 2018,10,97; DOI:10.3390/nu10010097

Krieg, Aumailley The extracellular matrix of the dermis: flexible structures with dynamic functions Experimental Dermatology 2011, 20, 689-695

Kumar, Sugihara, Suzuku, Inoue, Venkateswarathirukumara A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis J Sci Food Agric 2015;95:702-707

Lee, Ellman, Yan, Kroin, Cole, van Wijnen, Im: A current review of molecular mechanisms regarding osteoarthritis and pain Gene. 2013 Sept 25;527(2):440-447

Lemes, Sala, da Costa Ores, Cavalcante Braga, Egea, Fernandes A review oft the latest advances in encrypted bioactive peptides from protein-rich waste Int J Mol Sci 2016,17,950

Le Vu, Takatori, Iwamoto, Akagi, Satu, Totsuka, Chida, Sato, Shimizu Effects of food-derived collagen peptides on the expression of keratin and keratin-associated protein genes in the mouse skin Skin Pharmacol Physiol 2015;28:227-235

Liu, Machado, Eyles, Ravi, Hunter Dietary supplements for treating osteoarthritis: a syystematic review and meta-analysis Br J Sports Med 2017;0:1-10

Liu, Nikoo, Boran, Zhou, Regenstein Collagen and Gelatin Annu. Rev. Food Sci. Technol. 2015, 6:527-57 doi: 10.1146/annurev-food-031414-111800

Lozano-Montoya, Cerrera-Pérez, Abraha, Cherubini, O’Mahony, Cruz-Jentoft Nonpharmacological intervention to treat physical frailty and sarcopenia in older patients: a systematic overview – the SENATOR Project ONTOP series Cinical Interventions in Aging 2017:12 721-740

Luo, Lin Li, Liu Effect of nutritional supplement combined with exercise intervention on sarcopenia in the elderly: a meta-analysis International Journal of Nursing Science 4 (2017) 389-401 https://doi.org/10.1016/j.ijnss.2017.09.004

Manninen Hyperinsulinaemia, hyperaminoacidaemia and post-exercise muscle anabolism: the search for the optimal recovery drink Br J Sports Med 2006;40:900-905

Martin, Armstrong, Rodriguez Dietary protein intake and renal function Nutrition & Metabolism 2005, 2:25

McAlindon, Nuite, Krishnan, Ruthazer, Price, Burstein, Grifith, Flechsenhar Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial Osteoarthritis Cartilage 19(2011) 399-405

Minaguchi, Koyama, Meguri, Hosaka, Ueda, Kusubata, Hirota, Irie, Mafune, Takehana Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in achilles tendon J Nutr Sci Vitaminol 51, 169-174, 2005

Moskowitz Role of collagen hydrolysate in bone and joint disease Semin Arthritis Rheum 30:87-99 (2000)

Mouly, Lloret-Linares, Sellier, Sene Is the clinical relevance of drug-food and drug-herb interactions limites to grapefruit juice and Saint-John’s Wort? Pharmalogical Research 118(2017)82-92

Narici, Maganaris Plasticity of the muscle-tendon complex with disuse and aging Exercise and sport science reviewa Vol 35, No 3 (July 2007):126-134

Offengenden, Chakrabarti, Wu Chicken collagen hydrolysates differentially mediate anti-inflammatory activity and type I collagen synthesis on human dermal fibroblasts Food Science an Human Wellness 7(2018) 138-147 doi 10.1016/fshw.2018.02.002

Oikawa, McGlory, D’Souza, Morgan, Saddler, Baker, Parise, Phillips A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein synthesis during inactivity and energy restriction in older persons Am J Clin Nutr 2018;108:1-9

O’Keefe, Bergman, Carrera-Bastos, Fontes-Villalba, DiNicolantonio, Cordain Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa Open Heart2016;3:e000325, DOI:10.1136/openhrt-2015-000325

Oliva, Piccirilli, Berardi, Frizziero, Tarantino, Maffulli Hormones and tendinopathies: the current evidence Brit Med Bull 2016;117:39-58

Osawa, Mizushige, Jinno, Sugihara, Inoue, Tanaka, Kabuyama Absorption and metabolism of orally administered collagen hydrolysates evaluated by the vascularly perfused rat intestine and liver in situ Biomedical Research (Tokyo) 39 (1) 1-11 (2018)

Pak, Long, Annes, Witcher, Knadler, Ayan-Oshodi, Mitchell, Leese, Hillgren In vitro and clinical evaluations of the drug-drug interaction potential of a metabotropic glutamate 2/3 receptor agonist prodrug with intestinal peptide transporter 1 Drug Metab Dispos 45:137-144, Feb 2017

Paul, C., Leser, S., & Oesser, S. (2019). Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance. Nutrients, 11(5), 1079. doi:10.3390/nu11051079

Pencharz, Elango, Wolfe Recent developments in understanding protein needs – How much and what kind should we eat? Appl. Physiol. Nutr. Metab. 41: 577-580 (2016)

Pérez-Sánchez, Barrajón-Catalán, Herranz-López, Micol Nutraceuticals for skin care: a comprehensive review of human clinical studies Nutrients 2018, 10, 403

Phillips Current Concepts and Unresolved Questions in Dietary Protein Requirements ans Supplements in Adults Front. Nutr. 4:13 May 2017

Phillips, Chevalier, Leidy Protein “requirements” beyond the RDA: implications for optimizing health Appl. Physiol. Nutr. Metab. 41: 565-572 (2016)

Praet, Purdam, Welvaert, Vlahovich, Lovell, Burke, Gaida, Manzanero, Hughes, Waddington Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in achilles tendinopathy patients. Nutrients 2019, 11, 76; doi:10.3390/nu11010076

Proksch, Segger, Degwert, Schunk, Zague, Oesser Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlles study Skin Pharmacol Physiol 2014:27:47-55

Proksch, Schunk, Zague, Degwert, Oesser Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis Skin Pharmacol Physiol 2014;27:113-119

Razak, Begum, Viswanath, Rajagopal Multifarious beneficial effect of nonessential amino acid, glycine: a review Oxid Med Cell Longevity (2017) http://dx.doi.org/10.1155/2017/1716701

Reinke, Sorg Wound repair and regeneration Eur Surg Res 2012;49:35-43

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Robinson, Reginster, Rizzoli, Shaw, Kanis, Bautmans, Bischoff-Ferrari, Bruyère, Cesari, Dawson-Hughes, Fielding, Kaufman, Landi, Malafarina, Rolland, van Loon, Vellas, Visser, Cooper, EESCO working group Does nutrition play a role in the prevention and management of sarcopenia? Clinical Nutrition (2017) http://dx.doi.org/10.1016/j.clnu.2017.08.016

Rutherfurd-Marvick Food proteins as a source of bioactive peptides with diverse functions B J Nutr (2012), 108, S149-157

Schaafsma Safety of protein hydrolysates, fractions thereof and bioactive peptides in human nutrition Eur J Clin Nutr (2009) 63,1161-1168

Schadow, Simons, Lochnit, Kordelle, Gazova, Siebert, Steinmeyer Metabolic response of human osteoarthritic cartilage to biochemically characterized collagen hydrolysates Int J Mol Sci 2017,18,207

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Schunk, Louton, Oesser The effectiveness of specific collagen peptides on osteoarthritis in dogs – impact on metabolic processes in canine chondrocytes Open Journal of Animal Sciences, 2017,7,254-266

Schunk, Oesser Specific collagen peptides benefit the biosynthesis of matrix molecules of tendons and ligaments Journal of the International Society of Sports Nutrition 2013, 10(Suppl 1):P23

Schunk, Zague, Oesser, Proksch Dietary supplementation with specific collagen peptides has a body mass index-dependent beneficial effect on cellulite morphology J Med Food 18 (12) 2015, 1340-1348

Sharma, Mucino, Ronco Renal Functional Reserve and Renal Recovery after Acute Kidney Injury Nephron Clin Pract 2014;127:94-100

Sharma, Singh, Rana Bioactive Peptides: a Review Int. J Bioautomation, 2011, 15(4):223-50

Shaw, Lee-Barthel, Ross, Wang, Baar Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis Am J Clin Nutr 2017;105:136-43

Shigemura, Kubomura, Sato Y., Sato K. Dose-dependent changes in the level of free and peptide forms of hydroxyproline in human plasma after collagen hydrolysat ingestion Food Chemistry 159 (2014) 328-332

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Wu, Nerlich, Docheva Tendon injuries: basic science and new repair proposals EFORT Open Rev 2017;2:332-342 DOI: 10.1302/2058-5241.2.160075

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Zague, de Freitas, da Costa Rosa, de Castro, Jaeger, Machado-Santelli Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity J Med Food 14(6) 2011, 318-624

Zague, Bussador do Amaral, Rezende-Teixeira, de Oliveira Niero, Lauand, Machado-Santelli Collagen peptides modulate the metabolism of extracellular matrix by human dermal fibroblasts derived from sun-protected and sun-exposed body sites Cell Biol Int 42(2018):95-104

Zdzieblik, Oesser, Baumstark, Gollhofer, König Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial Br J Nutr (2015), 114, 1237-1245

Zdzieblik, Oesser, Gollhofer, König Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides Appl Physiol. Nutr. Metab. 42:588-595 (2017)